Alternate ending -- living on without telomerase
Scientists of the German Cancer Research Center have discovered an alternative mechanism for the extension of the telomere repeat sequence by DNA repair enzymes.
View ArticleNovel technique reveals dynamics of telomere DNA structure
Biomedical researchers studying aging and cancer are intensely interested in telomeres, the protective caps on the ends of chromosomes. In a new study, scientists at UC Santa Cruz used a novel...
View ArticleFanning the flames of tumor growth: Enzyme responsible for protecting...
Chromosomes are capped by long, repetitive DNA sequences called telomeres. These caps prevent genomic damage by insulating against the steady shortening of DNA ends that naturally accompanies...
View ArticleStudy shows potential new way to detect colorectal and other cancers
A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism...
View ArticleGenome instability studies could change treatment for cancer and other diseases
Counterintuitive as it may seem, genetic mutation is key to our evolution and survival.
View ArticleResearch resolves contradiction over protein's role at telomeres
Mice and humans share a lot more than immediately meets the eye, and their commonalities include their telomeres, protective ends on chromosomes. But in recent years, the role of one particular protein...
View ArticleStudy identifies new targeted treatment strategy for some aggressive cancers
Researchers from the Massachusetts General Hospital (MGH) Cancer Center and Boston University School of Medicine (BUSM) have identified the first potential treatment targeting a pathway by which...
View ArticleStudy in roundworm chromosomes may offer new clues to tumor genome development
A study of DNA rearrangements in roundworm chromosomes may offer new insight into large-scale genome duplications that occur in developing tumors.
View ArticleTeam creates a unique mouse model for the study of aplastic anaemia
Aplastic anaemia is characterised by a reduction in the number of the bone marrow cells that go on to form the different cell types present in blood (essentially red blood cells, white blood cells and...
View ArticleScientists find ethnicity linked to antibodies
(Medical Xpress)—Cracking the DNA code for a complex region of the human genome has helped 14 North American scientists, including five at Simon Fraser University, chart new territory in immunity...
View ArticleEpigenetic changes shed light on biological mechanism of autism
Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits. The...
View ArticlePrenatal smoke exposure may impact children's chromosomes
A new study published in the American Journal of Public Health finds prenatal exposure to cigarette smoke can impact parts of chromosomes in children.
View ArticleLatent virus and life expectancy
The telomeres are repetitive DNA sequences at each end of our chromosomes. Studies show that in every cell division, the telomere is shortened. As a result, the telomere limits the cell to a fixed...
View ArticleThe dark side of 'junk' DNA: Repeating DNA sequences play a role in bone cancer
The stretches of DNA between genes, littered with repeating sequences, were once considered the "junk of the genome," but scientists are learning that some of this junk is far from harmless clutter.
View ArticleGroundbreaking discovery has potential to improve therapies for cancer and...
The Retinoblastoma protein (pRB) has long been studied for its role in cell growth and the prevention of cancer. In a new study by Lawson Health Research Institute, scientists have discovered that pRB...
View ArticleScientists characterize regulatory DNA sequences responsible for human diseases
Scientists from the Children's Medical Center Research Institute at UT Southwestern (CRI) have developed an innovative system to identify and characterize the molecular components that control the...
View ArticleNew process could be key to understanding complex rearrangements in genome
Understanding complex genomic rearrangements (CGRs), the culprit in the development of many types of cancer and genetic disorders, has always been a challenge because of the limitations of established...
View ArticleTeam identifies DNA element that may cause rare movement disorder
A team of Massachusetts General Hospital (MGH) researchers has identified a specific genetic change that may be the cause of a rare but severe neurological disorder called X-linked dystonia...
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